Search DubaiPRNetwork.com

Home >> Healthcare & Medicine

Ground-breaking cellular therapy set to revolutionise treatment for children with leukaemia

Tuesday, February 13, 2018/ Editor -  

Share

Home >> Healthcare & Medicine

13 February 2018, Dubai, UAE:   This International Childhood Cancer Day, paediatric haematologist expert, Professor Ajay Vora, from Great Ormond Street Hospital in London (GOSH) discusses how advances in cellular therapy are set to revolutionise treatment for children with acute lymphoblastic leukaemia (ALL). 

Acute lymphoblastic leukaemia (also called ALL or acute lymphocytic leukaemia) is a cancer of the blood and bone marrow.  Leukaemia is one of the ten most common malignancies in Saudi Arabia, Kuwait and UAE, and a major form of paediatric cancer. In the UAE, a recent study found a high rate of ALL (32%) among males. 

According to Professor Vora, childhood leukaemia outcomes have improved in the past four decades, with 90% of children with ALL surviving. These improvements in outcomes have also translated for children in the Middle East as well. 

“There are a number of new pioneering treatments being developed at GOSH to treat leukaemia using immune cells, and some of these are being tested in clinical trials”, explains Prof. Vora. “These treatments are experimental and are only considered when routine chemotherapy treatments haven’t worked. A Kuwaiti patient will soon be the first international patient to receive CAR-T cell therapy at GOSH.”

CAR-T cell therapy, a type of cellular therapy currently being trialled at GOSH to treat ALL, involves collecting a patient’s own white blood cells (or immune cells) and modifying them so they can attack specific cancers.

“One major issue, especially in infants, is the difficulty in collecting enough of the right type of immune cells (T cells)”, Prof. Vora explains. “For such cases, new approaches are being tested that use T cells from a healthy donor but are modified using ‘gene-editing’ so they don’t need to be matched to the patient. This means the cells are ‘universal’ and can be produced in advance and stored frozen, ready to be used in multiple patients.” 

The gene-edited T cells (called UCART19) are given to patients immediately after a course of chemotherapy and antibody therapy. They are expected to circulate around the body and fight any leukaemia carrying the CD19 marker. Responses are assessed after one month, and if remission had been achieved, the patient will proceed to have a bone marrow transplant. At that stage the cells are removed and do not persist long-term.

This innovative treatment is currently available at GOSH as part of its research trials, and will become available in the near future to patients from across the world once the research phase is over. 

“Cellular therapy has the potential to revolutionise the treatment of leukaemia in children. Currently, it provides a chance to treat patients who have failed to respond to other treatment. If further research confirms preliminary data on efficacy, in future, it will provide a less toxic alternative to haemopoietic stem cell transplantation,” Prof. Vora concludes.

GOSH, who treats 1,500 children from the Middle East every year, has treated 271 haematology patients between April – Dec 2017.

 


Previous in Healthcare & Medicine

Next in Healthcare & Medicine


Home >> Healthcare & Medicine Section

Latest Press Release

Commitment and Protection – the increasing importance of DIFC Wills amid economi ...

RAYMOND WEIL Freelancer ACDC Limited Edition

Eberhard & Co. Scafograf Black Sheep

Saint Honore Allure Lady-Charming colour

NEP and Tata Communications complete the remote production of VIVO Indian Premie ...

Tommy Hilfiger introduces latest SS18 women's watch collection

Fatima Bint Hazza Inaugurates Abu Dhabi Ladies' Club

Orolia Awarded $34 Million Contract to Deliver Personnel Recovery Devices to the ...

Abu Dhabi International Airport Achieves Sustainability Milestone

Emirates Motor Company wins prestigious global award for outstanding customer se ...

Dubai Tourism Launches State-of-the-art Airport Installation to Inspire Dxb Tran ...

A Fresh New Look to the World's Oldest Islamic Bank

What's better than a good breakfast on your Birthday? One that is free!

Making the leap from leasing to UAE home owner

Dubai Shoppers Stand the Chance to Drive Home a Car on Spending Just AED 200

Dubai Customs showcases its experience to Chinese delegates

Back to the 90s with GUESS Originals

DC Aviation Group continues to grow its Aircraft Management fleet

Learn to enhance your body and home energy quotient

Hair Rituel by Sisley Now available at Paris Gallery